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by Bill Roberts – Two completely different stories can be found in the aromatase inhibitor letrozole.
In medical studies that measure the levels of estradiol and testosterone in the blood of hundreds of individuals, letrozole is a very consistent drug with almost no unusual behavior. The only odd behavior found in the scientific literature is in a very early publication by the pharmaceutical manufacturer that made it seem incredibly powerful but omitted many details. All the other studies have shown a relatively ordinary and consistent power.
My findings for more than ten years have coincided with these results.
The other story will be that even follow-up doses of letrozole will “eliminate” estrogen and that it is complicated to use for this reason.
If that is your personal experience with a given letrozole product, follow your adventure. However, if you are new to letrozole or have used it successfully before, I recommend that you consider it more difficult than any other aromatase inhibitor (AI), as this is my experience with many people.
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How much letrozole to use? As with all AIs, there is a significant personal variation, where a substantial number of users need only half of the majority, and some require even less. In all cases, the dose should be evaluated individually depending on the side effects observed and, preferably, also based on blood tests. But as a general guide, I recommend around 0.36 mg/day as the base amount for an anabolic steroid cycle with a modest amount of aromatizable steroids, such as 200-300 mg/week of testosterone. At a higher dose, such as 750 mg/week, this amount will usually double. In general, you should not take more than 1 mg/day unless the blood tests show abnormally high estradiol even at that level, but this is rarely the case.
Overdose will result in low levels of estradiol, which can result in adverse side effects of loss of libido, depression, joint pain, or flat-appearing musculature. If a high dose is not administered while using aromatizable steroids such as testosterone or Dianabol, abnormally high estradiol can also cause loss of libido or depression, can cause water retention and can cause or aggravate gynecomastia.
When you experience depression or loss of libido as the only side effects observed and unsure of whether the problem is due to an overdose or overdose, the blood test is the best way to resolve the question. Merely changing the dose and observing the result may be otherwise.
When it is desired to reduce the dose of letrozole, it is essential to take into account the half-life of two days of the drug. Due to the accumulation in the body, if you reduce the dose, the result will not be entirely seen for more than a week! However, you have a problem that must be corrected promptly.
Instead, allow the levels to fall during a short break. If, for example, you want to reduce the dose by half, take two days off completely, and then start reducing the dose. Or, if you’re going to reduce the dose by 25%, take a day off and then start the new dosage.
When beginning the use of letrozole, its half-life should also be taken into account. In general, when you use letrozole continuously when you take a dose, your body will receive not only the treatment you just made but also two days of cumulative doses. If on the first day of use, you take only one treatment, you will not have the necessary amount in your system. Instead, take the 3-dose value on the first day, and then use your regular daily dose. This will quickly lead to blood levels where they should be. If you do not do this, it will take approximately two weeks for blood levels to accumulate ultimately.
The use of letrozole during anabolic steroid cycles should generally be discontinued at the end of the last week of the period. However, if you know from experience that when you stop the cycle, a certain amount of letrozole optimizes your estradiol levels, the dose can be changed to that amount instead of being suspended.
As suggested above, in some cases, a person may have excessively high estrogen while not using anabolic steroids. Letrozole can work exceptionally well to normalize estradiol in these cases. For most men, 20 to 29 pg / mL of estradiol is the ideal range to aspire to, although some feel better in the 30s. The amount of letrozole needed will depend on the amount of correction required. When estradiol is well above the target range, 0.36 mg /